Reacción #164914

Ecuación de reacción

3-iodo-2-methyl-5-nitropyridine

acetic acid

→

5-iodo-6-methylpyridin-3-amine

Disolventes

ethanol

EtOAc

water

Na2CO3

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThen it was filtered
2. 2
   Extracciónextracted with EtOAc
3. 3
   Lavadothe organic extracts were washed with water, saturated NaCl
4. 4
   Secadodried (MgSO4)

Procedimiento

To a solution of 3-iodo-2-methyl-5-nitropyridine (125 mg, 0.4734 mmol) in ethanol (3 mL) was added acetic acid (0.50 mL, 8.8 mmol) and iron powder (140 mg, 2.6 mmol). The reaction was heated at 85° C. for 30 minutes and was diluted with EtOAc, water, and saturated Na2CO3. Then it was filtered and extracted with EtOAc and the organic extracts were washed with water, saturated NaCl, dried (MgSO4) and stripped in vacuo. 1H NMR (400 MHz, CDCl3): δ 7.96 (d, 1H), 7.44 (d, 1H), 3.57 (br s, 2H), 2.61 (s, 3H); MS (ES) (M+H)=235.

Fuente