Reacción #164750

Ecuación de reacción

sodium acetate trihydrate

benzyl N-allyl-N-(2-oxoethyl)carbamate

hydroxylamine hydrochloride

→

title compound

Rendimiento 90.3%

Benzyl N-allyl-N-[2-hydroxyiminoethyl]carbamate

Rendimiento 90.3%

Disolventes

water

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe acetonitrile is evaporated
2. 2
   Extracciónthe aqueous solution is extracted with ethyl acetate
3. 3
   OtroThe organic layer is separated
4. 4
   Secadodried over magnesium sulfate
5. 5
   Concentraciónconcentrated under vacuum

Procedimiento

A solution of benzyl N-allyl-N-(2-oxoethyl)carbamate (25 g, 107 mmol) in acetonitrile (150 mL) is treated with hydroxylamine hydrochloride (9.68 g, 139 mmol) and a solution of sodium acetate trihydrate (16 g, 117.9 mmol) in water (75 mL). The mixture is stirred at room temperature overnight. The acetonitrile is evaporated and the aqueous solution is extracted with ethyl acetate. The organic layer is separated, dried over magnesium sulfate, and concentrated under vacuum to give the title compound (24 g, 90%). ES/MS (m/e): 249 (M+H).

Fuente