Reacción #164105

Ecuación de reacción

dimethylamine

4-benzyl-4-((dimethylamino)methyl)cyclohexanone

potassium cyanide

hydrochloric acid

→

nitrile

4-benzyl-1-(dimethylamino)-4-((dimethylamino)methyl)cyclohexane carbonitrile

Disolventes

methanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónwas extracted with ether (4×150 mL)
2. 2
   ConcentraciónAfter the solution was concentrated
3. 3
   Secadodried overnight with magnesium sulphate
4. 4
   Filtraciónfiltered
5. 5
   Otrothe solvent was removed in a vacuum

Procedimiento

40% aqueous dimethylamine solution (2.8 mL, 22.1 mmol), 4-benzyl-4-((dimethylamino)methyl)cyclohexanone (1.13 g, 4.60 mmol) and potassium cyanide (0.70 g, 11.0 mmol) were added to a mixture of 4N hydrochloric acid (3 mL) and methanol (1.05 mL) with ice cooling. The mixture was stirred for 2 d at room temperature and then after adding water (200 mL) was extracted with ether (4×150 mL). After the solution was concentrated, the residue was taken up in dichloromethane (200 mL) and dried overnight with magnesium sulphate, filtered and the solvent was removed in a vacuum. The nitrile was obtained as an oil which was crystallised through.

Fuente