Reacción #164104

Ecuación de reacción

ether

ethyl-4-oxocyclohexane carboxylate

ethylene glycol

→

raw product

Rendimiento 74.0%

1,4-dioxaspiro[4,5]decane-8-carboxylic acid ethyl ester

Rendimiento 74.0%

Disolventes

toluol

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water and 5% sodium hydrogencarbonate solution (150 mL each)
2. 2
   SecadoThe organic phase was dried with sodium sulphate
3. 3
   Concentraciónconcentrated to low volume in a vacuum

Procedimiento

A solution of ethyl-4-oxocyclohexane carboxylate (28.9 g, 169 mmol), ethylene glycol (36.7 g, 33.0 mL, 592 mmol) and p-toluol sulphonic acid (380 mg, 2.0 mmol) in toluol (90 mL) was stirred overnight at room temperature. The reaction solution was poured into ether (150 mL) and washed with water and 5% sodium hydrogencarbonate solution (150 mL each). The organic phase was dried with sodium sulphate and concentrated to low volume in a vacuum. Since the raw product (26.8 g) was obtained in pure form, it could be directly converted further.

Fuente