Reacción #163386

Ecuación de reacción

N-[2-(4-ethynyl-phenyl)-1-methyl-ethyl]-acetamide

5-bromo-2-cyclopentyloxypyrimidine

DIPEA

→

N-{2-[4-(2-Cyclopentyloxy-pyrimidin-5-ylethynyl)-phenyl]-1-methyl-ethyl}-acetamide

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent is removed in vacuo
2. 2
   Otrothe residue is purified by HPLC (MeOH/H2O/TFA)

Procedimiento

To 33.1 mg (0.17 mmol) N-[2-(4-ethynyl-phenyl)-1-methyl-ethyl]-acetamide (I58.3) and 40.0 mg (0.17 mmol) 5-bromo-2-cyclopentyloxypyrimidine (I14.1) in 2.0 mL THF are added 11.6 mg (0.02 mmol) bis(triphenylphosphin)palladiumdichlorid, 1.57 mg (8.00 μmol) CuI and 56.0 μL (0.33 mmol) DIPEA. The reaction mixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue is purified by HPLC (MeOH/H2O/TFA).

Fuente