Reacción #163313

Ecuación de reacción

cyclopentanol

5-bromo-2-chloro-pyrimidine

NaH

→

5-Bromo-2-cyclopentyloxy-pyrimidine

Disolventes

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter removing of the cooling bath the reaction mixture
2. 2
   OtroThe reaction is quenched by the addition of water
3. 3
   OtroThe solvent is removed under vacuo
4. 4
   workup.DISSOLUTIONthe residue is dissolved in DCM
5. 5
   Lavadowashed with water
6. 6
   Secadodried with MgSO4
7. 7
   OtroThe solvent is removed under reduced pressure
8. 8
   OtroThe crude product is used without further purification

Procedimiento

36.3 μL (0.40 mmol) cyclopentanol and 38.7 mg (0.20 mmol) 5-bromo-2-chloro-pyrimidine are added to 1.5 mL dioxane and cooled down to 0° C. Then the reaction mixture is charged with 24.0 mg NaH. After removing of the cooling bath the reaction mixture is stirred at r.t. over night. The reaction is quenched by the addition of water. The solvent is removed under vacuo and the residue is dissolved in DCM, washed with water and dried with MgSO4. The solvent is removed under reduced pressure. The crude product is used without further purification.

Fuente