Reacción #162878

ord-1b654989558b42f98697e61c07af9fd1

Ecuación de reacción

c1cc2[nH]ncc2cc1NC1CC2CCC1N2
Intermediate 24
c1cc2[nH]ncc2cc1NC1CC2CCC1N2
N-((1SR,2RS,4RS)-7-azabicyclo[2.2.1]heptan-2-yl)-1H-indazol-5-amine
Cc1ccc(C=O)cc1NS(C)(=O)=O
N-(5-formyl-2-methylphenyl)methanesulfonamide
→
Cc1ccc(CN2C3CCC2C(Nc2ccc4[nH]ncc4c2)C3)cc1NS(C)(=O)=O
title compound
Cc1ccc(CN2C3CCC2C(Nc2ccc4[nH]ncc4c2)C3)cc1NS(C)(=O)=O
N-(5-(((1SR,2RS,4RS)-2-((1H-indazol-5-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methyl)-2-methylphenyl)methanesulfonamide

Reactantes

c1cc2[nH]ncc2cc1NC1CC2CCC1N2
Intermediate 24
c1cc2[nH]ncc2cc1NC1CC2CCC1N2
N-((1SR,2RS,4RS)-7-azabicyclo[2.2.1]heptan-2-yl)-1H-indazol-5-amine
Cc1ccc(C=O)cc1NS(C)(=O)=O
N-(5-formyl-2-methylphenyl)methanesulfonamide

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Reaction of Intermediate 24 with N-(5-formyl-2-methylphenyl)methanesulfonamide affords the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08835457B2uspto-grants-2014_09