Reacción #162867

Ecuación de reacción

Compound 8

(2S)-tert-butyl 2-(4-(4′-(2-((3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-imidazol-4-yl)biphenyl-4-yl)-1H-imidazol-2-yl)octahydro-1H-indole-1-carboxylate

water

→

(2S)-2-(4-(4′-(2-((3S)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-imidazol-4-yl)biphenyl-4-yl)-1H-imidazol-2-yl)octahydro-1H-indole

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroResulting
2. 2
   Otroreaction
3. 3
   TemperaturaThe resulting slurry was cooled to RT
4. 4
   FiltraciónFiltration of the slurry
5. 5
   Otroafforded a solid
6. 6
   Lavadowashed with 15 ml acetone
7. 7
   Otrodried directly
8. 8
   Otroused in the next reaction

Procedimiento

Compound 8 were taken in 9 ml methanol; 1 ml Conc. HCL and 0.2 ml water was added. Resulting reaction was stirred for 5 h at 50° C. (oil bath temp) completed, after completion of the reaction monitor by HPLC. The resulting slurry was cooled to RT and held with agitation for about 1H. Filtration of the slurry afforded a solid; washed with 15 ml acetone dried directly used in the next reaction.

Fuente