Reacción #162766

Ecuación de reacción

3-bromobenzyl bromide

4,4-difluoro-piperidine hydrochloride

potassium carbonate

→

title compound

Rendimiento 99.4%

1-(3-Bromo-benzyl)-4,4-difluoro-piperidine

Rendimiento 99.4%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered
2. 2
   Otroevaporated
3. 3
   Otrothe residue partitioned between water (30 mL) and EtOAc (3×30 mL)
4. 4
   LavadoThe combined organic extracts were washed with water (2×50 mL)
5. 5
   Secadodried (Na2SO4)
6. 6
   OtroThe solvent was evaporated

Procedimiento

A mixture of 3-bromobenzyl bromide (3.43 g, 13.73 mmol), 4,4-difluoro-piperidine hydrochloride (2.20 g, 13.97 mmol), and potassium carbonate (4.82 g, 34.86 mmol) in acetonitrile (50 mL) was stirred at RT for 16 h. The mixture was filtered and evaporated, and the residue partitioned between water (30 mL) and EtOAc (3×30 mL). The combined organic extracts were washed with water (2×50 mL) and dried (Na2SO4). The solvent was evaporated to give the title compound as a colourless oil (3.96 g, 99%). LCMS (Method 1): Rt 1.89 min, m/z 290/292 [MH+].

Fuente