Reacción #162256

Ecuación de reacción

2,4-diphenylaniline

1-bromo-2-fluorobenzene

sodium

→

2,4-diphenyl-N-2-fluorophenylbenzenamine

Rendimiento 61.9%

Disolventes

toluene

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrois removed
2. 2
   ExtracciónThe reaction mixture is extracted with dichloromethane and water
3. 3
   workup.DISTILLATIONbeing distilled under reduced pressure
4. 4
   FiltraciónThe resulting residence is filtered by silica gel column
5. 5
   workup.DISTILLATIONdistilled under reduced pressure again
6. 6
   OtroNext, by re-crystallizing
7. 7
   Filtraciónfiltering with dichloromethane and petroleum ether

Procedimiento

2,4-diphenylaniline (12 mmol), 1-bromo-2-fluorobenzene (10 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.15 mmol), (±)-2,2′-bis(diphenylphosphine)-1,1′-binaphthalene (0.3 mmol) and sodium tert-butoxie (14 mmol) are put in a two-neck round-bottom flask and dissolved in toluene (30 mL). Subsequently, the resulting solution is stirred in a bath under a temperature of about 100° C. for 24 hours. After completion of the reaction, toluene is removed. The reaction mixture is extracted with dichloromethane and water, and then being distilled under reduced pressure. The resulting residence is filtered by silica gel column and distilled under reduced pressure again. Next, by re-crystallizing and filtering with dichloromethane and petroleum ether, 2,4-diphenyl-N-2-fluorophenylbenzenamine (2.1 g) is yielded.

Fuente