Reacción #1617

Ecuación de reacción

Lithium aluminium hydride

5-Benzyloxy-2-hydroxy benzoic acid methyl ester

→

4-benzyloxy-2-hydroxymethyl phenol

Disolventes

tetrahydrofuran

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was warmed to room temperature
2. 2
   TemperaturaThe reaction was then cooled to 0° C.
3. 3
   Otrocautiously quenched by the addition of water (0.5 ml), 2M sodium hydroxide solution (0.5 ml), and water (1 ml)
4. 4
   workup.STIRRINGThe resulting mixture was stirred at room temperature for 30 minutes
5. 5
   Filtraciónfiltered
6. 6
   OtroThe filtrate was evaporated in vacuo

Procedimiento

Lithium aluminium hydride (0.235 g, 6.2 mMol) was suspended in tetrahydrofuran (25 ml) and cooled to 0° C. 5-Benzyloxy-2-hydroxy benzoic acid methyl ester (2 g, 7.75 mMol) in tetrahydrofuran (10 ml) was added dropwise, via cannula. The mixture was warmed to room temperature and stirred for 20 minutes. The reaction was then cooled to 0° C. and cautiously quenched by the addition of water (0.5 ml), 2M sodium hydroxide solution (0.5 ml), and water (1 ml). The resulting mixture was stirred at room temperature for 30 minutes and filtered. The filtrate was evaporated in vacuo to yield 4-benzyloxy-2-hydroxymethyl phenol as a clear oil which was used in the next step without further purification.

Fuente