Reacción #161460

Ecuación de reacción

water

benzoxazole

2-(2-(tetrahydrofuran-2-yl)methylaminoanilin-5-yl)benzoxazole

methyl acetimidate hydrochloride

→

title compound

Rendimiento 127.5%

5-(benzoxazol-2-yl)-2-methyl-1-(tetrahydrofuran-2-yl)methylbenzimidazole

Rendimiento 127.5%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathis was heated
2. 2
   Temperaturato reflux for 3 hours
3. 3
   TemperaturaAfter the reaction solution was cooled
4. 4
   Filtraciónthe precipitated crystals were filtered
5. 5
   Lavadoafter being washed with water
6. 6
   Otrowere dried

Procedimiento

To a solution of 2-(tetrahydrofuran-2-yl)methylaminoanilin-5-yl)benzoxazole (see Working Example 95-1) (0.15 g, 0.4 mmol) in methanol (5 mL) was added methyl acetimidate hydrochloride (0.05 mg, 0.4 mmol), and this was heated to reflux for 3 hours. After the reaction solution was cooled, water was added, and the precipitated crystals were filtered, and after being washed with water were dried to yield the title compound (0.17 g, 79% yield) as white crystals.

Fuente