Reacción #161132

Ecuación de reacción

4-tert-butyl-phenylamine

NBS

→

2-Bromo-4-tert-butyl-phenylamine

Disolventes

DMF

DMF

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with EtOAc
2. 2
   LavadoThe organic layer was washed with water, brine
3. 3
   Secadodried over Na2SO4
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe crude product was directly used in the next step without further purification

Procedimiento

To a solution of 4-tert-butyl-phenylamine (447 g, 3 mol) in DMF (500 mL) was added dropwise NBS (531 g, 3 mol) in DMF (500 mL) at room temperature. Upon completion, the reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated. The crude product was directly used in the next step without further purification.

Fuente