Reacción #161119

ord-ed116ac2db13497eaec502a4321fada4

Ecuación de reacción

O=[N+]([O-])c1ccc2cc[nH]c2c1
6-nitroindole
CCOC(=O)CI
iodo-acetic acid ethyl ester
→
CCOC(=O)Cc1c[nH]c2cc(N)ccc12
(6-Amino-1H-indol-3-yl)-acetic acid ethyl ester

Reactantes

O=[N+]([O-])c1ccc2cc[nH]c2c1
6-nitroindole
CCOC(=O)CI
iodo-acetic acid ethyl ester

Reactivos

Ninguno

Disolventes

CC#N
CH3CN

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroOverall yield (24%)

Procedimiento

(6-Amino-1H-indol-3-yl)-acetic acid ethyl ester (B-17) was synthesized following the general scheme above starting from 6-nitroindole and iodo-acetic acid ethyl ester. Overall yield (24%). HPLC ret. time 0.95 min, 10-99% CH3CN, 5 min run; ESI-MS 219.2 m/z (MH+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08829204B2uspto-grants-2014_09