Reacción #1605841

Ecuación de reacción

dibenzylcarbamoyl chloride

dehydro-aripiprazole

→

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2-yl dibenzylcarbamate

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture heated
2. 2
   Temperaturaat reflux for 4 h
3. 3
   ConcentraciónThe reaction mixture was concentrated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate (ethyl acetate)
5. 5
   Lavadowashed with water
6. 6
   Secadodried over MgSO4
7. 7
   OtroAfter evaporation the residue
8. 8
   Otrowas further purified on silica eluting with ethyl acetate
9. 9
   Otroafter drying
10. 10
    Otrogave Compound-342 (0.71 g) as a white solid

Procedimiento

To a solution of dibenzylcarbamoyl chloride (1.7 g, 6.7 mmol) in pyridine (15 mL) was added dehydro-aripiprazole (1.5 g, 3.4 mmol) and the reaction mixture heated at reflux for 4 h. The reaction mixture was concentrated and the residue co-evaporated with toluene (×3). The residue was dissolved in ethyl acetate (ethyl acetate), washed with water and dried over MgSO4. After evaporation the residue was further purified on silica eluting with ethyl acetate and after drying gave Compound-342 (0.71 g) as a white solid.

Fuente