Reacción #1605816

Ecuación de reacción

boron tribromide

4-Methoxy-2-nitro-1-phenylbenzene

→

3-nitro-4-phenylphenol

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added, under ice-water cooling
2. 2
   workup.ADDITIONthe reaction mixture was poured onto ice
3. 3
   Otrothe reaction
4. 4
   Extracciónextracted with ethyl acetate
5. 5
   LavadoThe organic layer was washed with a saturated aqueous solution of sodium chloride
6. 6
   Secadodried over anhydrous magnesium sulfate
7. 7
   Concentraciónconcentrated under reduced pressure

Procedimiento

4-Methoxy-2-nitro-1-phenylbenzene (1.86 g, 8.31 mmol) was dissolved in dichloromethane (40 mL) and thereto was added, under ice-water cooling, a solution of boron tribromide (2 mL) in dichloromethane (10 mL) After stirring at room temperature for 18 hours, the reaction mixture was poured onto ice to stop the reaction and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 3-nitro-4-phenylphenol as a crude material.

Fuente