Reacción #1605812

Ecuación de reacción

2-Phenyl-N-acetylaniline

hydrogen bromide

→

2-phenyl-4-bromo-N-acetylaniline

Rendimiento 91.3%

Disolventes

carbon tetrachloride

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe solution was concentrated under reduced pressure, to the residue
2. 2
   workup.ADDITIONwas added water (20 mL) and subsequently ethanol (30 mL)
3. 3
   workup.STIRRINGthe mixture was stirred under ice bath for 1 hour
4. 4
   FiltraciónThe precipitate was collected by filtration
5. 5
   Lavadowashed with ethanol/water (=1:1)
6. 6
   Otrodried under reduced pressure

Procedimiento

2-Phenyl-N-acetylaniline (6.21 g, 29.40 mmol) was dissolved in acetic acid (70 mL). Thereto was dropwise added under ice bath a separately prepared solution of hydrogen bromide (6.14 g, 38.42 mmol) dissolved in carbon tetrachloride (19.21 mL) and the mixture was stirred at room temperature overnight. The solution was concentrated under reduced pressure, to the residue was added water (20 mL) and subsequently ethanol (30 mL), and the mixture was stirred under ice bath for 1 hour. The precipitate was collected by filtration, washed with ethanol/water (=1:1), dried under reduced pressure to obtain 2-phenyl-4-bromo-N-acetylaniline (7.79 g).

Fuente