Reacción #1605805

Ecuación de reacción

4-(3-Amino-4-phenylphenyl)butyric acid

tosylic acid hydrate

water

→

benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate

Rendimiento 171.2%

Disolventes

toluene

benzyl alcohol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added
2. 2
   Temperaturathe mixture was heated
3. 3
   Otroremoved by a Dean-Stark trap
4. 4
   ConcentraciónThe reaction solution was concentrated under reduced pressure
5. 5
   Otroa solid obtained
6. 6
   Lavadowas washed with a mixed solvent of hexane-ethyl acetate (4:1)
7. 7
   FiltraciónThe solid was collected by filtration
8. 8
   Otrodried under reduced pressure

Procedimiento

To a suspension of 4-(3-Amino-4-phenylphenyl)butyric acid (21.6 g, 84.6 mmol) in toluene (300 mL), benzyl alcohol (50 mL) and tosylic acid hydrate (17.7 g, 93.0 mmol) were added, and the mixture was heated under reflux for 5 hours with water removed by a Dean-Stark trap. The reaction solution was concentrated under reduced pressure and a solid obtained was washed with a mixed solvent of hexane-ethyl acetate (4:1). The solid was collected by filtration and dried under reduced pressure to obtain benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate (41.2 g).

Fuente