Reacción #1605795

Ecuación de reacción

5-Acetyl-8-hydroxy-1H-quinolin-2-one

potassium carbonate

benzyl bromide

→

5-acetyl-8-benzyloxy-1H-quinolin-2-one

Rendimiento 87.4%

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe insoluble matter was removed by filtration
2. 2
   Lavadowashed with N,N-dimethylformamide
3. 3
   workup.ADDITIONThe filtrate and the washing were mixed
4. 4
   Concentraciónconcentrated under reduced pressure
5. 5
   workup.ADDITIONTo the residue was added
6. 6
   Otropurified water (3.3 L)
7. 7
   workup.STIRRINGthe mixture was stirred at room temperature overnight
8. 8
   FiltraciónThe precipitate was collected by filtration
9. 9
   Lavadowashed with purified water
10. 10
    Otrodried under vacuum

Procedimiento

5-Acetyl-8-hydroxy-1H-quinolin-2-one (430 g, 2.12 mol) was suspended in N,N-dimethylformamide (3.3 L), potassium carbonate (298 g, 2.16 mol) and subsequently benzyl bromide (298 g, 2.11 mol) were added thereto, and the mixture was stirred at room temperature for 2 hours. The insoluble matter was removed by filtration and washed with N,N-dimethylformamide. The filtrate and the washing were mixed and concentrated under reduced pressure. To the residue was added purified water (3.3 L) and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with purified water, and dried under vacuum to obtain 5-acetyl-8-benzyloxy-1H-quinolin-2-one (541 g).

Fuente