Reacción #1605772

Ecuación de reacción

NH3

2-methoxy-4-methylbenzoic acid

EDC

HOBt

→

2-methoxy-4-methylbenzamide

Rendimiento 83.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothen washed successively with HCl (1N)
2. 2
   SecadoNaHCO3, water and brine, dried over MgSO4
3. 3
   Filtraciónfiltered
4. 4
   Otroevaporated
5. 5
   OtroThe residue was recrystallized from ethyl acetate/hexane

Procedimiento

To a mixture of 2-methoxy-4-methylbenzoic acid (20 g, 120.4 mmol), EDC (23.1 g, 120.4 mmol) and HOBt (16.3 g, 120.4 mmol) in dichloromethane (1 L) was added NH3 (7N in MeOH, 52 mL, 3 eq) dropwise. The reaction mixture was stirred at room temperature overnight then washed successively with HCl (1N), saturated aq.NaHCO3, water and brine, dried over MgSO4, filtered and evaporated. The residue was recrystallized from ethyl acetate/hexane to give 16.5 gr of 2-methoxy-4-methylbenzamide (83% yield).

Fuente