Reacción #160530

Ecuación de reacción

water

dimethyl-(4-nitro-2-trifluoromethylphenyl)amine

(4-chlorophenoxy)acetonitrile

potassium tert-butoxide

→

title compound

Rendimiento 9.9%

(5-Dimethylamino-2-nitro-4-trifluoromethylphenyl)acetonitrile

Rendimiento 9.9%

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthis mixture was extracted with ethyl acetate
2. 2
   LavadoThis organic layer was washed with water and brine
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   OtroThe solvent was removed under reduced pressure
5. 5
   OtroThe residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)

Procedimiento

To a solution of dimethyl-(4-nitro-2-trifluoromethylphenyl)amine (0.95 g) in N,N-dimethylformamide (20 mL) were added (4-chlorophenoxy)acetonitrile (0.75 g) and 1 mol/L potassium tert-butoxide (4.5 mL, in tetrahydrofuran solution) under ice cooling, and this mixture was stirred at the same temperature for 1 hour. This reaction mixture was poured into water, and this mixture was extracted with ethyl acetate. This organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.11 g).

Fuente