Reacción #160512

Ecuación de reacción

(Z)-3-(5-benzyloxy-2-bromo-4-methylphenyl)-2-benzyloxycarbonylaminoacrylic acid methyl ester

cesium acetate

ammonia

→

title compound

Rendimiento 63.1%

5-Benzyloxy-6-methyl-1H-indole-2-carboxylic acid methyl ester

Rendimiento 63.1%

Disolventes

dimethylsulfoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe precipitated solid was collected by filtration
2. 2
   Lavadowashed with water
3. 3
   Otrodried under reduced pressure

Procedimiento

To a solution of (Z)-3-(5-benzyloxy-2-bromo-4-methylphenyl)-2-benzyloxycarbonylaminoacrylic acid methyl ester (0.2 g) and copper (I) iodide (0.075 g) in dimethylsulfoxide (8 mL) was added cesium acetate (0.38 g) at room temperature and this mixture was stirred under argon atmosphere at 90° C. for 5 hours. To this reaction mixture was added aqueous ammonia solution (28%) and the precipitated solid was collected by filtration, and washed with water, dried under reduced pressure to give the title compound (0.073 g).

Fuente