Reacción #160428

Ecuación de reacción

(1-ethylpyrrolidin-2-yl)methylamine

1-Ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride

5-formyl-2,4-dimethyl-1H-pyrrole-3-formic acid

1-hydroxybenzotriazole

→

N-[(1-ethylpyrrolidin-2-yl) methyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide

Rendimiento 47.6%

Disolventes

DMF

triethylamine

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGto stir for 1.5 hrs
2. 2
   workup.STIRRINGThe reaction was stirred at room temperature until completion
3. 3
   Extracciónthe mixture was extracted with 10% methanol/dichloromethane (300 mL×3)
4. 4
   LavadoThe combined organic phase was washed with saturated salt water (300 mL×3)
5. 5
   Secadodried over anhydrous Na2SO4
6. 6
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
7. 7
   OtroThe residue was chromatographed on silica gel (eluted with methanol/ethyl acetate=1/1)

Procedimiento

1-Ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (268.1 g, 1.4 mol), triethylamine (280.0 mL), 5-formyl-2,4-dimethyl-1H-pyrrole-3-formic acid (167.0 g, 1.0 mol) and 1-hydroxybenzotriazole (189.2 g, 1.4 mol) were added to DMF (500 mL) with stirring at about 0° C. and allowed to stir for 1.5 hrs, and then (1-ethylpyrrolidin-2-yl)methylamine (1.2 mol) was added. The reaction was stirred at room temperature until completion was indicated by thin layer chromatography (TLC). 120 mL of water and 100 mL of saturated salt water were added, and the mixture was extracted with 10% methanol/dichloromethane (300 mL×3). The combined organic phase was washed with saturated salt water (300 mL×3), dried over anhydrous Na2SO4, and the solvent was distilled off under reduced pressure. The residue was chromatographed on silica gel (eluted with methanol/ethyl acetate=1/1) to afford 131.86 g (476 mmol) of N-[(1-ethylpyrrolidin-2-yl) methyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide as an off-white solid. Yield 47.6%, m.p. 166-169° C.

Fuente