Reacción #160051

Ecuación de reacción

N-benzyl-2-methyl-prop-2-en-1-amine

tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate

→

tert-butyl 4-[[benzyl(2-methylallyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

Rendimiento 100.1%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was cooled
2. 2
   Concentraciónconcentrated in vacuo

Procedimiento

A mixture of N-benzyl-2-methyl-prop-2-en-1-amine (0.57 g, 3.52 mmol) and tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (0.75 g, 3.52 mmol) in ethanol (4 mL) was heated at 80° C. in a sealed vial for 16 hours. The reaction mixture was cooled and concentrated in vacuo to give tert-butyl 4-[[benzyl(2-methylallyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate (1.32 g, 100%) as a colorless oil. ESI-MS m/z calc. 374.5. Found 375.7 (M+1)+; Retention time: 1.24 minutes (3 min run).

Fuente