Reacción #159955

Ecuación de reacción

Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxyate

monoethyl malonate

piperidine

→

title compound

Rendimiento 47.7%

Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxyate

Rendimiento 47.7%

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe precipitate was recovered by filtration
2. 2
   LavadoThe precipitate was washed with water
3. 3
   Otrodried
4. 4
   Temperaturaunder heating

Procedimiento

Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxyate 470 mg, monoethyl malonate 378 mg, piperidine 0.05 mL and pyridine 6 mL were mixed and stirred at 100° C. for 38 hours. Ice water was added to the reaction liquid and the precipitate was recovered by filtration. The precipitate was washed with water and dried in flowing air under heating to provide 311 mg of the title compound.

Fuente