Reacción #1597199

Ecuación de reacción

6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthoic acid

4-(aminomethyl)-N-(2-aminophenyl)benzamide

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title compound

Rendimiento 82.0%

N-(4-((2-aminophenyl)carbamoyl)benzyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide

Rendimiento 82.0%

Condiciones de reacción

Procedimiento

The title compound (49.0 mg, 82% yield) was prepared as a brown solid from 6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthoic acid (37.5 mg, 0.1 mmol) and 4-(aminomethyl)-N-(2-aminophenyl)benzamide (28.9 mg, 0.12 mmol) by an analogous procedure to that described in example 16. 1H NMR (DMSO-d6) δ 3.93 (s, 3H, —OCH3), 3.95 (s, 3H, —OCH3), 4.63 (d, J=5.6 Hz, 2H, —CH2), 4.90 (s, 2H, benzene-NH2), 6.56-6.59 (m, 2H, Ar—H), 6.78 (d, J=7.6 Hz, 1H, Ar—H), 6.96 (t, J=8.1 Hz, 1H, Ar—H), 7.17 (d, J=7.6 Hz, 1H, Ar—H), 7.42 (s, 1H, Ar—H), 7.53-7.55 (m, 4H, Ar—H), 7.62 (t, J=8.0 Hz, 1H, Ar—H), 7.71 (d, J=6.8 Hz, 1H, Ar—H), 7.87 (s, 1H, Ar—H), 7.98-8.06 (m, 3H, Ar—H), 8.39 (d, J=9.2 Hz, 1H, Ar—H), 8.49 (d, J=5.2 Hz, 1H, Ar—H), 9.26 (t, J=6.0 Hz, 1H, —CONH), 9.66 (s, 1H, benzene-NH). LC-MS (m/z) 599 (M+1).

Fuente