Reacción #1597173

Ecuación de reacción

N-(2-aminophenyl)-4-cyanobenzamide

sulfuric acid

hydrogen

→

title compound

Rendimiento 96.2%

4-(aminomethyl)-N-(2-aminophenyl)benzamide

Rendimiento 96.2%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered through celite
2. 2
   FiltraciónThe resulting mixture was filtered
3. 3
   Otrothe filtrate was evaporated under vacuum

Procedimiento

To a solution of N-(2-aminophenyl)-4-cyanobenzamide (237 mg, 1 mmol) in methanol (40 ml) was added sulfuric acid (196 mg, 1 mmol) and 5% palladium on charcoal (0.20 g). The mixture was stirred under an atmosphere of hydrogen at room temperature until hydrogen uptake ceased. The mixture was filtered through celite, and the filtrate was neutralized with 1 N NaOH solution in methanol (2 ml). The resulting mixture was filtered, and the filtrate was evaporated under vacuum to give the title compound (232 mg, 96% yield) as a grey solid. LC-MS (m/z) 242 (M+1).

Fuente