Reacción #1596995

ord-84289a27ef1a4e41b17689cb80d0be1e

Ecuación de reacción

Nc1ccc(O)c(C(=O)O)c1
5-aminosalicylic acid
O=[N+]([O-])c1ccc(CBr)cc1
4-nitrobenzyl bromide
→
O=C(O)c1cc(NCc2ccc([N+](=O)[O-])cc2)ccc1O
5-(4-nitrobenzyl)aminosalicylic acid
Rendimiento 79.0%

Reactantes

Nc1ccc(O)c(C(=O)O)c1
5-aminosalicylic acid
O=[N+]([O-])c1ccc(CBr)cc1
4-nitrobenzyl bromide

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroin Synthesis Example 1

Procedimiento

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (2.00 g, 13.0 mmole) and 4-nitrobenzyl bromide (3.38 g, 15.6 mmole), 2.90 g (79% yield) of 5-(4-nitrobenzyl)aminosalicylic acid was obtained as a pale yellow solid.:mp 211-212° C.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08211877B2uspto-grants-2012_07