Reacción #1596945

Ecuación de reacción

2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran

triethylamine

→

2-fluoro-4-(5-propyltetrahydropyran-2-yl)phenol

Disolventes

MTBE

toluene water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe organic phase is separated off
2. 2
   ExtracciónThe aqueous phase is extracted with MTBE
3. 3
   LavadoThe combined organic phases are washed with water
4. 4
   Otrodried
5. 5
   ConcentraciónThe solution is concentrated to dryness
6. 6
   Otrothe residue is used directly for the following reaction

Procedimiento

123.0 g (0.30 mol) of 2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran are hydrogenated in toluene/water in the presence of Pd/C (5% of Pd) and 86.0 ml (0.60 mol) of triethylamine. The reaction solution is diluted with MTBE, and the organic phase is separated off. The aqueous phase is extracted with MTBE. The combined organic phases are washed with water and dried using sodium sulfate. The solution is concentrated to dryness, and the residue is used directly for the following reaction.

Fuente