Reacción #1596940

Ecuación de reacción

phenyl isothiocyanate

2-amino-2-methyl-1-propanol

→

N-(1-hydroxy-2-methylpropan-2-yl)-N′-phenylthiourea

Rendimiento 60.0%

Disolventes

chloroform

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas slowly added dropwise to the mixture over one hour
2. 2
   workup.ADDITIONUpon completion of the addition
3. 3
   workup.STIRRINGthe resulting mixture was stirred for 12 hours at room temperature
4. 4
   TemperaturaThe precipitated crystals were refluxed
5. 5
   Temperaturawith heat
6. 6
   workup.DISSOLUTIONto be dissolved
7. 7
   Otrorecrystallized
8. 8
   OtroThe crystals thus obtained
9. 9
   Filtraciónwere collected by filtration
10. 10
    Lavadowashed with 20 mL of diethyl ether three times
11. 11
    Otrodried under reduced pressure at room temperature

Procedimiento

In 500 g of chloroform was dissolved 2-amino-2-methyl-1-propanol (61.6 g, 0.69 moL). Then, 300 g of chloroform solution containing phenyl isothiocyanate (81.6 g, 0.6 moL) was slowly added dropwise to the mixture over one hour, while stirring. Upon completion of the addition, the resulting mixture was stirred for 12 hours at room temperature. The precipitated crystals were refluxed with heat to be dissolved and then recrystallized. The crystals thus obtained were collected by filtration, washed with 20 mL of diethyl ether three times, and then dried under reduced pressure at room temperature to give 80.1 g of N-(1-hydroxy-2-methylpropan-2-yl)-N′-phenylthiourea (yield 60%).

Fuente