Reacción #159392

ord-da7c56f6377842599c8942a175a6d475

Ecuación de reacción

COC(=O)c1sc(CCC2CC2)cc1N=CN(C)C
5-(2-Cyclopropylethyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester
CN(CCS(C)(=O)=O)[C@@H]1CCN(c2ccc(N)cc2)C1
[(R)-1-(4-aminophenyl)pyrrolidin-3-yl]-(2-methanesulfonylethyl)methylamine
→
CN(CCS(C)(=O)=O)[C@@H]1CCN(c2ccc(-n3cnc4cc(CCC5CC5)sc4c3=O)cc2)C1
6-(2-Cyclopropylethyl)-3-(4-{(R)-3-[(2-methanesulfonylethyl)methylamino]pyrrolidin-1-yl}phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

Reactantes

COC(=O)c1sc(CCC2CC2)cc1N=CN(C)C
5-(2-Cyclopropylethyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester
CN(CCS(C)(=O)=O)[C@@H]1CCN(c2ccc(N)cc2)C1
[(R)-1-(4-aminophenyl)pyrrolidin-3-yl]-(2-methanesulfonylethyl)methylamine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe product with the molecular weight of 500.57 (C25H32N4O3S2) was obtained in this way

Procedimiento

5-(2-Cyclopropylethyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester was reacted with [(R)-1-(4-aminophenyl)pyrrolidin-3-yl]-(2-methanesulfonylethyl)methylamine by method A1. The product with the molecular weight of 500.57 (C25H32N4O3S2) was obtained in this way; MS (ESI): 501 (M+H+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08828991B2uspto-grants-2014_09