Reacción #159376

Ecuación de reacción

4-fluoro-2-methyl-1-nitrobenzene

dimethylpyrrolidin-3-ylamine

potassium carbonate

→

Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was partitioned between water and ethyl acetate
2. 2
   OtroThe organic phase was dried
3. 3
   Concentraciónconcentrated
4. 4
   OtroThe product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way

Procedimiento

A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).

Fuente