Reacción #159374

Ecuación de reacción

3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester

dimethoxymethyldimethylamine

→

5-(4-Chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction solution was partitioned between water and ethyl acetate
2. 2
   SecadoThe organic phase was dried over magnesium sulfate
3. 3
   Concentraciónconcentrated
4. 4
   OtroThe product with the molecular weight of 322.82 (C15H15ClN2O2S) was obtained in this way

Procedimiento

A solution of 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester (5.0 g) in DMF (30 μL) was mixed with dimethoxymethyldimethylamine (5 mL) and stirred for 36 hours. The reaction solution was partitioned between water and ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 322.82 (C15H15ClN2O2S) was obtained in this way; MS (ESI): 323 (M+H+).

Fuente