Reacción #159176

Ecuación de reacción

2-Bromo-1-(3a,6a-dihydro-thieno[3,2-b]thiophen-2-yl)-ethanone

Boc-proline

MeCN

→

title compound

Rendimiento 61.0%

Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[2-(3a,6a-dihydro-thieno[3,2-b]thiophen-2-yl)-2-oxo-ethyl]ester

Rendimiento 61.0%

Disolventes

Triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónthen concentrated
2. 2
   OtroThe crude residue was purified by silica column chromatography (14% to 35% EtOAc/Hex)

Procedimiento

Crude 2-Bromo-1-(3a,6a-dihydro-thieno[3,2-b]thiophen-2-yl)-ethanone (2.48 mmol assuming complete conversion from starting material) was treated with Boc-proline and MeCN (25 mL). Triethylamine was added and the solution was stirred at RT for 1 h then concentrated. The crude residue was purified by silica column chromatography (14% to 35% EtOAc/Hex) to afford the title compound (595 mg, 61%).

Fuente