Reacción #159015

Ecuación de reacción

2-[5-(6-Bromonaphthalen-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

trifluoroacetic acid

→

5-(6-Bromo-naphthalen-2-yl)-2-pyrrolidin-2-yl-1H-imidazole

Rendimiento 98.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroevaporated under vacuum
2. 2
   workup.DISSOLUTIONSolid was dissolved in dichloromethane (50 mL)
3. 3
   Extracciónextracted with saturated NaHCO3 solution (50 mL)
4. 4
   FiltraciónSolid was collected by vacuum filtration
5. 5
   Lavadowashed with dichloromethane
6. 6
   Otrodried under vacuum

Procedimiento

2-[5-(6-Bromonaphthalen-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (5.03 g) was dissolved in dichloromethane (75 mL), and trifluoroacetic acid (25 mL) was added. The reaction mixture was stirred at ambient temperature for 5 hours and evaporated under vacuum. Solid was dissolved in dichloromethane (50 mL) and extracted with saturated NaHCO3 solution (50 mL). Solid was collected by vacuum filtration, washed with dichloromethane, and dried under vacuum, giving 5-(6-Bromo-naphthalen-2-yl)-2-pyrrolidin-2-yl-1H-imidazole (98%) as an off-white solid.

Fuente