Reacción #1590

Ecuación de reacción

p-chlorobenzoylpropionic acid

nitric acid

→

4-chloro-3-nitrobenzoylpropionic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroslowly portionwise at 0° C
2. 2
   workup.ADDITIONAfter the addition
3. 3
   Filtraciónthe resulting white solid was suction filtered
4. 4
   Lavadowashed with water until the pH of the washing liquids
5. 5
   Otrodried
6. 6
   Otroto yield 3-(4-chloro-3-nitrobenzoyl)propionic

Procedimiento

To fuming nitric acid (150 ml) was added p-chlorobenzoylpropionic acid (20.0 g), slowly portionwise at 0° C. After the addition was completed the resulting mixture was stirred at 0° C. for 30 minutes and the resulting white solid was suction filtered and washed with water until the pH of the washing liquids was neutral, then dried to yield 3-(4-chloro-3-nitrobenzoyl)propionic add as a white solid (13.0 g).

Fuente