Reacción #158850

Ecuación de reacción

2-Bromo-5-methylpyridine

carbon tetrachloride

NBS

→

2-bromo-5-bromomethylpyridine

Rendimiento 105.4%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting mixture was heated
2. 2
   Temperaturaat reflux overnight
3. 3
   Otrothe NBS was removed by filtration
4. 4
   ConcentraciónThe filtrate was concentrated

Procedimiento

To a solution of 2-Bromo-5-methylpyridine (3.1 g, 17.4 mmol) in carbon tetrachloride (40 mL, 400 mmol) was added benzoyl peroxide (230 mg, 950 μmol) and NBS (3.4 g, 19.2 mmol). The resulting mixture was heated at reflux overnight. The mixture was cooled at 0° C. and the NBS was removed by filtration. The filtrate was concentrated to yield 2-bromo-5-bromomethylpyridine (4.6 g), which was used directly in the next step.

Fuente