Reacción #158715

Ecuación de reacción

1,4-diaminobenzene

ethyl isocyanate

potassium carbonate

→

4-(ethylaminocarbonylamino)aniline

Rendimiento 62.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was partitioned in 1N HCl solution (80 mL)
2. 2
   ExtracciónThe aqueous layer was extracted with ethyl acetate (4×80 mL)
3. 3
   OtroThe combined organic layers was dried
4. 4
   Otroevaporated
5. 5
   Otrorecrystallized from MeOH/CH2Cl2/hexanes

Procedimiento

A mixture of 1,4-diaminobenzene (4 g, 37 mmol), ethyl isocyanate (1 mL, 12.6 mmol) and potassium carbonate (8.72 g, 63 mmol) in THF (20 mL) was stirred at room temperature overnight. The reaction mixture was partitioned in 1N HCl solution (80 mL) and ethyl acetate (80 mL). The aqueous layer was extracted with ethyl acetate (4×80 mL). The combined organic layers was dried, evaporated, recrystallized from MeOH/CH2Cl2/hexanes to give 4-(ethylaminocarbonylamino)aniline (1.4 g, 62%) as a beige solid.

Fuente