Reacción #1584857

Ecuación de reacción

3-chloro-pyrazine-2-carboxylic acid

ethyl potassium malonate

3-(3-fluoro-pyridin-2-yl)-3-oxo-propionic acid ethyl ester

→

3-(3-Chloro-pyrazin-2-yl)-3-oxo-propionic acid ethyl ester

Rendimiento 39.5%

Condiciones de reacción

Procedimiento

3-(3-Chloro-pyrazin-2-yl)-3-oxo-propionic acid ethyl ester (12) (2 g, 39.54%) was synthesized as a yellow liquid from 3.5 g of 3-chloro-pyrazine-2-carboxylic acid (11) and 5.64 g of ethyl potassium malonate (2) following the procedure described for 3-(3-fluoro-pyridin-2-yl)-3-oxo-propionic acid ethyl ester (3).

Fuente