Reacción #158392

Ecuación de reacción

5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole

5-chloropent-1-yne

triethylamine

→

title compound

5-[4-(5-chloropent-1-yn-1-yl)-2-methoxyphenyl]-2-methyl-1,3-oxazole

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe mixture was filtered through celite
2. 2
   OtroThe solvent was evaporated under reduced pressure
3. 3
   Otrothe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Procedimiento

A mixture of 5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole (6.00 g), 5-chloropent-1-yne (4.74 mL), dichlorobis(triphenylphosphine)palladium(II) (1.57 g), copper(I) iodide (426 mg) and triethylamine (60 mL) was stirred at 70° C. for 3 hr, and diluted with ethyl acetate, and the mixture was filtered through celite. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (4.85 g).

Fuente