Reacción #1583853

Ecuación de reacción

codeine phosphate

→

Codeine

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONslowly adding 1,856 g of AMBERLITE™
2. 2
   workup.ADDITIONThe dispersion was mixed for 4 hours and upon completion
3. 3
   Otrobefore decanting the supernatant
4. 4
   OtroThe wet resin complex was then dried at VWR™ convection oven
5. 5
   workup.ADDITIONEUDRAGIT™NE-30D polymer system (668 g) was mixed with 1,150 g of purified water
6. 6
   workup.ADDITIONslowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
7. 7
   Otroto form a uniform mass
8. 8
   OtroThe wet mass was dried at 50° C. in a VWR™ convection oven to the moisture content around 3-7%
9. 9
   OtroThe dried granules were then milled through 40 mesh screen

Procedimiento

The Codeine Resin Complex was prepared by first dissolving 500 g of codeine phosphate in 5 kg of purified water, and then slowly adding 1,856 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried at VWR™ convection oven maintained at 50° C. until moisture content was about 20-30%. EUDRAGIT™NE-30D polymer system (668 g) was mixed with 1,150 g of purified water and then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was dried at 50° C. in a VWR™ convection oven to the moisture content around 3-7%. The dried granules were then milled through 40 mesh screen using CO-MIL™ brand mill.

Fuente