Reacción #1583817

Ecuación de reacción

sulphuric acid

N-benzyl-4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine-2-amine

sodium hydroxide

→

4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine-2-amine

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture is extracted with dichloromethane (3×100 ml)
2. 2
   SecadoThe combined organic phases are dried over MgSO4
3. 3
   OtroThe residue is triturated with MTBE
4. 4
   Filtraciónfiltered off
5. 5
   OtroThe product obtained

Procedimiento

With ice cooling, 23 ml of conc. sulphuric acid are added to 4.75 g (10.9 mmol) of N-benzyl-4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine-2-amine, and the reaction mixture is stirred at room temperature for 30 min. The reaction mixture is stirred into 100 ml of ice-water, the pH is adjusted to 10 using concentrated aqueous sodium hydroxide solution and the mixture is extracted with dichloromethane (3×100 ml). The combined organic phases are dried over MgSO4 and freed from the solvent under reduced pressure. The residue is triturated with MTBE and filtered off. The product obtained is 2.80 g (82%) of a beige solid; log P (pH2.7): 1.29 with MS (ESI): 300.1 ([M+H]+).

Fuente