Reacción #158333

Ecuación de reacción

1-(4-bromo-2-methoxyphenyl)-3-methyl-1H-1,2,4-triazole

5-hexyn-1-ol

triethylamine

→

title compound

6-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]hex-5-yn-1-ol

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool to room temperature
2. 2
   Filtraciónthe mixture was filtered through celite
3. 3
   OtroThe solvent was evaporated under reduced pressure
4. 4
   Otrothe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Procedimiento

A mixture of 1-(4-bromo-2-methoxyphenyl)-3-methyl-1H-1,2,4-triazole (3.00 g), 5-hexyn-1-ol (2.45 mL), dichlorobis(triphenylphosphine)palladium(II) (786 mg), copper(I) iodide (213 mg) and triethylamine (110 mL) was stirred at 70° C. for 14 hr, allowed to cool to room temperature, and diluted with ethyl acetate, and the mixture was filtered through celite. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (2.80 g).

Fuente