Reacción #158291

Ecuación de reacción

ammonium chloride

sodium ethoxide

diethyl (3,4-difluorophenyl)propanedioate

Acrylonitrile

→

title compound

diethyl (2-cyanoethyl)(3,4-difluorophenyl)propanedioate

Disolventes

tert-butylalcohol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature overnight
2. 2
   Extracciónthe mixture was extracted with ethyl acetate
3. 3
   LavadoThe extract was washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine
4. 4
   Secadodried over anhydrous sodium sulfate
5. 5
   OtroThe solvent was evaporated under reduced pressure

Procedimiento

Under an argon atmosphere, sodium ethoxide (20% ethanol solution, 1.7 g) was added to a mixture of diethyl (3,4-difluorophenyl)propanedioate (13.8 g) in tert-butylalcohol (50 mL) at room temperature, and the mixture was stirred at 40° C. for 30 min. Acrylonitrile (3.34 mL) was added to the reaction mixture at room temperature, and the mixture was stirred at room temperature overnight. Saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (15.2 g).

Fuente