Reacción #157969

Ecuación de reacción

tert-butyl[(1-benzyl-4-methylpiperidin-4-yl)methyl]carbamate

→

tert-butyl[(4-methylpiperidin-4-yl)methyl]carbamate

Rendimiento 103.1%

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter argon purge
2. 2
   Otrothe reaction liquid
3. 3
   Filtraciónwas filtered through Celite
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

20% palladium hydroxide on carbon (283 mg) was added to an EtOH (100 ml) solution of tert-butyl[(1-benzyl-4-methylpiperidin-4-yl)methyl]carbamate (2.57 g), and stirring was performed at 70° C. under a hydrogen atmosphere of medium pressure of 3 kgf/cm2 for 16 hours. After argon purge the reaction liquid was filtered through Celite and concentrated under reduced pressure to obtain tert-butyl[(4-methylpiperidin-4-yl)methyl]carbamate (1.90 g).

Fuente