Reacción #157640

ord-c990bffadb5046c0ad5c0c4c5de14139

Ecuación de reacción

COC(=O)c1ccc(CSc2ccc(F)cc2N)cc1
methyl 4-(((2-amino-4-fluorophenyl)thio)methyl)benzoate
O=S(=O)(Cl)c1cc2ccccc2o1
benzofuran-2-sulfonyl chloride
→
COC(=O)c1ccc(CSc2ccc(F)cc2NS(=O)(=O)c2cc3ccccc3o2)cc1
title compound
Rendimiento 66.0%
COC(=O)c1ccc(CSc2ccc(F)cc2NS(=O)(=O)c2cc3ccccc3o2)cc1
methyl 4-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-fluorophenyl}sulfanyl)methyl]benzoate
Rendimiento 66.0%

Reactantes

COC(=O)c1ccc(CSc2ccc(F)cc2N)cc1
methyl 4-(((2-amino-4-fluorophenyl)thio)methyl)benzoate
O=S(=O)(Cl)c1cc2ccccc2o1
benzofuran-2-sulfonyl chloride

Reactivos

Ninguno

Disolventes

c1ccncc1
pyridine

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Following General Procedure B, the title compound (929 mg, 66%) was prepared from methyl 4-(((2-amino-4-fluorophenyl)thio)methyl)benzoate (873 g, 2.99 mmol) and benzofuran-2-sulfonyl chloride (646 mg, 2.99 mmol) in pyridine (5 ml).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08822530B2uspto-grants-2014_09