Reacción #157609

Ecuación de reacción

6-cyanobenzothiazole

hydrazine monohydrate

→

title compound

Rendimiento 97.2%

4-Amino-3-mercaptobenzonitrile

Rendimiento 97.2%

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated
2. 2
   workup.ADDITIONH2O was added to the residue
3. 3
   FiltraciónThe resulting yellow precipitate was filtered
4. 4
   Lavadowashed with H2O
5. 5
   Otrodried under high vacuum

Procedimiento

A mixture of 6-cyanobenzothiazole (532 mg, 3.33 mmol) and hydrazine monohydrate (1.2 ml, 24.76 mmol) in EtOH (10 ml) was heated at 80° C. under N2 atmosphere for 2 hours. The solvent was evaporated, H2O was added to the residue, and the solution was adjusted to pH˜5-7 with AcOH. The resulting yellow precipitate was filtered and washed with H2O, dried under high vacuum to yield the title compound as yellow solid (486 mg, 97%).

Fuente