Reacción #157561

Ecuación de reacción

NH4Cl

N-(5-fluoro-2-((3-nitrobenzyl)thio)phenyl)benzofuran-2-sulfonamide

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title product

Rendimiento 59.0%

N-{2-[(3-aminobenzyl)thio]-5-fluorophenyl}-1-benzofuran-2-sulfonamide

Rendimiento 59.0%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe solid was filtered
2. 2
   Concentraciónthe filtrate was concentrated in vacuo
3. 3
   Otrothe crude residue was purified by column chromatography (0˜30% EtOAc in hexane)

Procedimiento

N-(5-fluoro-2-((3-nitrobenzyl)thio)phenyl)benzofuran-2-sulfonamide (91 mg, 0.199 mmol) was dissolved in MeOH (2 ml). Zn (322 mg, 4.967 mmol) and NH4Cl (1 ml) was added to the solution. After the mixture was stirred for 30 min at room temperature, the solid was filtered and the filtrate was concentrated in vacuo and then the crude residue was purified by column chromatography (0˜30% EtOAc in hexane) to afford the title product (50 mg, 59%).

Fuente