Reacción #157231

ord-ef9400d3894a442fb193c41fb139a7e4

Ecuación de reacción

COc1cc(C(=O)c2csc(-c3ccccc3)n2)cc(OC)c1OC
compound 1h
COc1cc(C(=O)c2csc(-c3ccccc3)n2)cc(OC)c1OC
(2-Phenyl-thiazol-4-yl)-(3,4,5-trimethoxy-phenyl)-methanone
O=C(O)C1CSC(c2cc3ccccc3[nH]2)=N1
2-(1H-indol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
N[C@@H](CS)C(=O)O
cysteine
O=C(c1ccc2[nH]ccc2c1)c1csc(-c2cc3ccccc3[nH]2)n1
(2-(1H-indol-2-yl)thiazol-4-yl)(1H-indol-5-yl)methanone

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

(2-(1H-indol-2-yl)thiazol-4-yl)(1H-indol-5-yl)methanone (21) was prepared using the similar method as used of compound 1h from 2-(1H-indol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid and cysteine. 1H NMR (500 MHz, CDCl3) δ 9.60 (s, 1H), 9.26 (s, 1H), 8.31 (s, 1H), 8.03 (s, 1H), 7.83 (dd, 1H), 7.69 (d, 1H), 7.53-7.49 (m, 2H), 7.41 (t, 1H), 7.33 (t, 1H), 7.21-7.18 (m, 2H), 7.13 (s, 1H). MS (ESI) m/z 366.1 (M+Na)+, 341.9 (M−H)−.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08822513B2uspto-grants-2014_09