Reacción #157166

ord-f52de13f530b4a0494cf483614d7b74c

Ecuación de reacción

CC(C)(C)OC(=O)N[C@H]1C[C@@H](F)CN(c2ccncc2N)C1
tert-Butyl (3S,5R)-1-(3-aminopyridin-4-yl)-5-fluoropiperidin-3-ylcarbamate
Nc1ccc(Br)nc1C(=O)O
3-amino-6-bromopicolinic acid
→
CC(C)(C)OC(=O)N[C@H]1C[C@@H](F)CN(c2ccncc2NC(=O)c2nc(Br)ccc2N)C1
tert-butyl (3S,5R)-1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-5-fluoropiperidin-3-ylcarbamate

Reactantes

CC(C)(C)OC(=O)N[C@H]1C[C@@H](F)CN(c2ccncc2N)C1
tert-Butyl (3S,5R)-1-(3-aminopyridin-4-yl)-5-fluoropiperidin-3-ylcarbamate
Nc1ccc(Br)nc1C(=O)O
3-amino-6-bromopicolinic acid

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Following Method 11 of Example 305, tert-Butyl (3S,5R)-1-(3-aminopyridin-4-yl)-5-fluoropiperidin-3-ylcarbamate and 3-amino-6-bromopicolinic acid were coupled yielding after column chromatography tert-butyl (3S,5R)-1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)-5-fluoropiperidin-3-ylcarbamate. LC/MS (m/z): 509.1/511.1 (MH+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08822497B2uspto-grants-2014_09